Lesson 11
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Peyronies Disease

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15 March, 2023
What Is Peyronies Disease (PD)?

Peyronie’s disease is a condition that affects the penis and is named after Francois de la Peyronie, a French surgeon who first described the condition in 1743. Peyronie’s disease is also known as induratio penis plastica or IPP. It is a disorder in which the penis becomes curved (curved penis), often making it difficult to have sex or causing pain during erections.


Peyronie’s disease is a condition in which scar tissue, also known as plaque, forms inside the penis. This plaque can cause the penis to bend or curve when erect (abnormal curvature), and can also cause pain or discomfort during erections. The degree of curvature can vary from person to person, with some individuals experiencing only a slight bend, while others may experience a more severe curvature. Peyronie’s disease can also cause other symptoms, such as erectile dysfunction (ED) and a shortening of the penis.

Incidence & Prevalence Of Peyronies Disease In India


The exact incidence of Peyronie’s disease in India is not known, as there are no comprehensive studies on the subject. However, it is estimated that the incidence of the condition is similar to that of other developed countries, which is about 3% to 9% of the male population.


The prevalence of Peyronie’s disease in India is also difficult to determine, as the condition is often underreported or misdiagnosed. It is believed that the prevalence of the condition in India is lower than in western countries. This may be due to cultural factors, such as a reluctance to seek medical help for sexual problems, as well as differences in lifestyle and genetics.

Diagnosis of Paraphimosis

Diagnosis of Paraphimosis Disease

There are several steps involved in the diagnostic process for Peyronie’s disease. These may include:

Medical History

Your health care provider will ask you questions about your symptoms, medical history, and sexual activity. This information will help them determine if you are at risk for Peyronie’s disease and if further testing is necessary.

Physical Exam

Your health care provider will perform a physical exam, which may include an examination of the penis. They will look for any lumps or plaques on the penis and may also evaluate the curvature or bending of the penis during an erection.

Imaging Tests

If your health care provider suspects Peyronie’s disease, they may order imaging tests such as an ultrasound or magnetic resonance imaging (MRI). These tests can help visualize the penis and any plaques or scar tissue that may be causing the curvature.

Erectile Function Tests

Your health care provider may also order tests to evaluate your erectile function. This may include a penile plethysmography, which measures blood flow to the penis during an erection, or a nocturnal penile tumescence test, which measures the frequency and strength of erections during sleep.

Blood Tests

In some cases, your healthcare provider may order blood tests to evaluate your overall health and rule out other medical conditions that may be causing your symptoms.


The symptoms of Peyronie’s disease can vary from person to person, and some men may not experience any symptoms at all. The most common symptoms of Peyronie’s disease include:

Curvature of the penis

The curvature of the penis is the most common symptom of Peyronie’s disease. The curvature can be mild or severe and may occur at any point along the penis.


Peyronie’s disease can cause penile pain, especially during an erection. The pain may be mild or severe and can make sexual intercourse uncomfortable or even impossible.


Peyronie’s disease can cause the formation of plaque in the penis. The plaque can feel like a hard lump under the skin and can cause the penis to become misshapen or lumpy.

Erectile dysfunction

Peyronie’s disease can cause erectile dysfunction, which is the inability to achieve or maintain an erection sufficient for sexual intercourse.

Shortening of the penis

Peyronie’s disease can cause the penis to become shorter, which can make sexual intercourse difficult or impossible.


Diagnosis of Peyronie’s disease: Peyronie’s disease is usually diagnosed based on the symptoms and a physical examination. The doctor may ask about the patient’s medical history and perform a physical exam to check for any lumps or abnormalities in the penis. The doctor may also order an ultrasound or other imaging tests to check for the presence of plaque in the penis.

Risk Factors

While the exact cause of Peyronie’s disease is not fully understood, there are several known risk factors that can increase a man’s likelihood of developing this condition.


Age is a significant risk factor for Peyronie’s disease. Men over the age of 40 are more likely to develop this condition than younger men. This is because the tissues in the penis become less elastic with age, making them more susceptible to injury and scarring.


Peyronie’s disease tends to run in families, so there is a genetic component to this condition. If a man has a family history of Peyronie’s disease, he is at a higher risk of developing the condition himself.

Trauma or injury to the penis

One of the most common risk factors for Peyronie’s disease is trauma or injury to the penis. This can be the result of an accident, sports injury, or even rough sexual activity. When the penis is injured, scar tissue can form, which can cause the penis to bend or curve during an erection.

Connective tissue disorders

Some connective tissue disorders, such as Dupuytren’s contracture, can also increase a man’s risk of developing Peyronie’s disease. These disorders cause abnormal fibrous tissue growth, which can lead to scarring and bending of the penis.


Smoking is a risk factor for many health problems, including Peyronie’s disease. Nicotine and other chemicals in cigarettes can damage blood vessels, leading to reduced blood flow to the penis. The association with cigarette smoking can increase the risk of scar tissue formation and curvature of the penis.

Certain medical conditions

Certain medical conditions, such as diabetes (high blood sugar) and high blood pressure, can also increase a man’s risk of developing Peyronie’s disease. These conditions can damage blood vessels and lead to reduced blood flow to the penis, which can increase the risk of scar tissue formation.

Certain medications

Some medications, such as beta-blockers and antidepressants, can increase the risk of Peyronie’s disease. These medications can cause reduced blood flow to the penis, which can increase the risk of scar tissue formation and curvature of the penis.


Nonsurgical Treatments

Oral Medications: One of the most common non-surgical treatments for Peyronie’s disease is oral medication, specifically phosphodiesterase type 5 (PDE5) inhibitors such as sildenafil, tadalafil, and vardenafil. These medications help increase blood flow to the penis and improve erections, which can reduce the pain and discomfort associated with the condition. However, they do not correct the curvature of the penis.


Topical Medications: Another non-surgical treatment option is the application of topical medications, such as verapamil and potassium aminobenzoate, to the affected area. These medications work by breaking down the scar tissue and reducing inflammation. While these topical medications may be less effective than other treatment options, they are typically well-tolerated and have fewer side effects.


Injection Therapy: Another non-surgical treatment for Peyronie’s disease is injection therapy. This involves the injection of medication directly into the scar tissue within the penis. The most commonly used medication for injection therapy is Xiaflex, which works by breaking down the collagen that causes the curvature of the penis. Injection therapy is typically administered in a series of treatments, with each injection spaced several weeks apart.

Surgical Approaches

Penile Plication: Penile plication is a surgical procedure that involves the use of sutures to straighten the penis. This procedure is typically performed under general anesthesia, and involves making incisions in the tissue of the penis and then suturing the tissue together to reduce the curvature. Penile plication is a relatively quick procedure, typically taking less than an hour to complete, and can result in minimal scarring and a quick recovery time.


Penile Prosthesis: For men with more severe cases of Peyronie’s disease, a penile prosthesis may be recommended. This involves the insertion of an inflatable device into the penis, which allows the user to achieve an erection on demand. While this is a more invasive procedure than other treatment options, it can be highly effective for men who have difficulty achieving erections due to the curvature of the penis.


Penile Grafting: Penile grafting involves the removal of scar tissue from the penis and the insertion of a graft of healthy tissue to replace it. This procedure is typically reserved for men with severe cases of Peyronie’s disease, as it is a more invasive procedure than other treatment options.


While the physical symptoms of Peyronie’s disease are often the focus of treatment, there are also several potential complications associated with this condition.

One of the most significant complications of Peyronie’s disease is erectile dysfunction. Patients with Erectile Dysfunction are unable to achieve or maintain an erection sufficient for sexual activity. Erectile dysfunction can be caused by the physical changes to the penis that occur with Peyronie’s disease, including curvature, narrowing, or shortening of the penis. Additionally, the emotional stress and anxiety that often accompany this condition can further contribute to erectile dysfunction.

Another common complication of Peyronie’s disease is pain or discomfort during sexual activity. The curvature or abnormal shape of the penis can cause pain or discomfort during penetration, making sexual activity difficult or impossible. This can lead to feelings of frustration, embarrassment, or anxiety, which can further impact a person’s sexual function and overall well-being.

Psychological Distress

Peyronie’s disease can also cause significant psychological distress, including anxiety, depression, and feelings of embarrassment or shame. The physical changes to the penis can impact a person’s self-esteem and body image, which can lead to avoidance of sexual activity or social situations. This can create a vicious cycle, where avoidance leads to further psychological distress, and further distress leads to increased avoidance.

Relationship Problems

Peyronie’s disease can also impact a person’s intimate relationships. The physical symptoms of the condition can make sexual activity difficult or impossible, which can strain a person’s relationship with their partner. Additionally, the emotional distress associated with this condition can impact communication, trust, and intimacy in a relationship. Without proper treatment, Peyronie’s disease can lead to a breakdown in communication and connection between partners.

Penile Deformity

In some cases, Peyronie’s disease can cause permanent deformity of the penis. This can include a significant curvature, shortening of the penis, or narrowing of the urethra. In severe cases, these deformities can impact a person’s ability to urinate or achieve an erection, leading to further physical and psychological complications.

Recurrence Of Curvature

The short answer is that there is a possibility that the curvature can return after Peyronie’s disease treatment. However, the likelihood of recurrence depends on a number of factors, including the severity of the initial curvature, the type of treatment received, and the individual’s overall health and lifestyle.


In cases where the curvature is mild, medication or penile injections may be prescribed to help reduce pain and prevent further curvature. In these cases, the likelihood of the curvature coming back after treatment is relatively low. However, if the curvature is severe or if there is significant scar tissue present, surgery may be required to correct the curvature. In these cases, there may be a higher likelihood of recurrence, particularly if the individual does not take proper care of their penis following surgery.


In order to minimize the risk of recurrence after Peyronie’s disease treatment, it is important to follow all post-treatment instructions provided by the healthcare provider. This may include abstaining from sexual activity for a period of time, avoiding strenuous activity or heavy lifting, and taking any prescribed medications as directed.


Additionally, maintaining good overall health and practicing healthy habits can help to reduce the risk of recurrence. This includes eating a healthy diet, getting regular exercise, and avoiding smoking or excessive alcohol consumption. These lifestyle changes can help to improve blood flow to the penis and promote overall penile health.

Urethral Injury And Peyronie’s Disease: The Correlation

Urethral injury is a condition that occurs when the urethra, the tube that carries urine and semen out of the body, is damaged. This can happen due to a variety of reasons, such as trauma, surgery, or a catheterization procedure. Symptoms of urethral injury include pain, swelling, difficulty urinating, and blood in the urine or semen.


While urethral injury and Peyronie’s disease are two separate conditions, they can be correlated in some cases. One theory is that the scar tissue that develops in Peyronie’s disease can also affect the urethra, leading to urethral strictures or narrowing. This can cause difficulty with urination and may require surgical intervention to correct.


Another theory is that the trauma or injury that leads to urethral injury can also cause the development of Peyronie’s disease. This is because the penis is a delicate organ that is susceptible to injury, and trauma to the penis can lead to the formation of scar tissue.

Autoimmune Disorders And Peyronie’s Disease: The Correlation

Autoimmune diseases are a group of conditions where the body’s immune system attacks its own tissues, leading to inflammation and damage. There are over 80 types of autoimmune diseases, and they can affect various parts of the body. Peyronie’s disease is a condition that affects the penis, causing it to curve and causing painful erections. There has been some research to suggest a possible correlation between autoimmune diseases and Peyronie’s disease.


Autoimmune diseases can affect any part of the body, including the connective tissues that make up the penis. These connective tissues include collagen, which helps give the penis its shape and strength. When the immune system attacks the collagen in the penis, it can cause Peyronie’s disease. Peyronie’s disease can also cause inflammation, which can further exacerbate the immune response and lead to more tissue damage.


Research has shown that certain autoimmune diseases may increase the risk of developing Peyronie’s disease. For example, a study published in the International Journal of Impotence Research found that men with rheumatoid arthritis, an autoimmune disease that affects the joints, were more likely to develop Peyronie’s disease than men without the condition. Another study published in the Journal of Sexual Medicine found that men with lupus, another autoimmune disease, were also more likely to develop Peyronie’s disease.


It is important to note that not all men with autoimmune diseases will develop Peyronie’s disease. However, if you have an autoimmune disease and are experiencing symptoms such as penile curvature or painful erections, it is important to speak with your healthcare provider. They can perform a physical exam and possibly recommend imaging tests to determine if you have Peyronie’s disease.

Mental Health And Peyronie’s Disease: The Correlation

man facing the mental issues due to Peyronie's Disease

Studies have shown that individuals with Peyronie’s disease are at an increased risk for anxiety and depression. The emotional distress of dealing with a curved penis can lead to feelings of shame, embarrassment, and even isolation. It’s important to recognize the potential emotional impact of Peyronie’s disease and seek appropriate support.


One factor that may contribute to the mental health impact of Peyronie’s disease is the stigma surrounding the condition. Many individuals may feel ashamed or embarrassed to talk about their symptoms, which can lead to feelings of isolation and a lack of support. It’s important to recognize that Peyronie’s disease is a medical condition, and seeking treatment is a vital part of managing the condition and maintaining good mental health.


Treating Peyronie’s disease can also have a positive impact on mental health. For example, treatments like penile traction therapy and medication have been shown to be effective in reducing the curvature associated with Peyronie’s disease, which can lead to increased confidence and a better self-image. This, in turn, can lead to improved mental health outcomes.


It’s important to address both the physical and mental health aspects of Peyronie’s disease. Seeking support from mental health professionals can be beneficial in managing the emotional distress associated with the condition. Additionally, seeking treatment for Peyronie’s disease can help improve physical symptoms, which can positively impact mental health.


If you or someone you know is experiencing symptoms of Peyronie’s disease, it’s important to seek medical attention and support. Recognizing the potential impact on mental health is an important part of managing the condition and maintaining overall well-being. With proper treatment and support, individuals with Peyronie’s disease can lead fulfilling lives and manage both the physical and emotional symptoms associated with the condition.

Sexual health is as important as physical and mental health. In most cases, one consultation can go a long way. Personalised, discreet, and judgement-free treatment at your fingertips – book an online consultation with one of Allo’s leading experts.