What is Siphene?

Siphene is a brand name for the medication clomiphene citrate, which is commonly used in the treatment of female infertility. Clomiphene citrate belongs to a class of drugs called selective estrogen receptor modulators (SERMs) and works by blocking estrogen receptors in the hypothalamus, which leads to an increase in follicle-stimulating hormone (FSH) and luteinizing hormone (LH) production, ultimately resulting in the release of an egg from the ovary (ovulation).

Siphene is typically used in women who are not ovulating regularly or who have irregular menstrual cycles. It may also be used in combination with other fertility treatments, such as intrauterine insemination (IUI) or in vitro fertilization (IVF). Siphene is available in tablet form and is usually taken for five days at the beginning of a menstrual cycle. As with all medications, it is important to talk to your doctor about the potential benefits and risks of using Siphene before starting treatment.

How Does Siphene Tablet Work?

Siphene (clomiphene citrate) works by blocking the action of estrogen in the hypothalamus, a region of the brain that regulates the production of hormones involved in the menstrual cycle. This blockade leads to an increase in the production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the pituitary gland, which in turn stimulates the ovaries to produce and release eggs.

To understand how Siphene works, it’s helpful to know a bit about the normal hormonal regulation of the menstrual cycle. The menstrual cycle is a complex process that involves the interplay of several hormones, including estrogen, progesterone, FSH, and LH. In a normal cycle, estrogen levels rise gradually in the first half of the cycle, leading to the development of a follicle (a fluid-filled sac in the ovary that contains an egg) and thickening of the uterine lining. As estrogen levels peak, the pituitary gland releases a surge of LH, which triggers ovulation (the release of the egg from the follicle). After ovulation, the ruptured follicle (now called the corpus luteum) produces progesterone, which prepares the uterus for possible implantation of a fertilized egg.

In some women, however, hormonal imbalances can disrupt this process, leading to irregular menstrual cycles or anovulation (lack of ovulation). One common cause of these imbalances is polycystic ovary syndrome (PCOS), a condition in which the ovaries produce too much androgen (a male hormone) and too little estrogen. Another possible cause is hypothalamic amenorrhea, a condition in which the hypothalamus fails to produce enough GnRH (gonadotropin-releasing hormone), a hormone that stimulates the release of FSH and LH from the pituitary gland.

Siphene works by blocking the action of estrogen in the hypothalamus, which leads to an increase in GnRH secretion and subsequent production of FSH and LH. The increased FSH and LH levels stimulate the ovaries to produce and release eggs, even in women who are not ovulating regularly or who have irregular menstrual cycles. Siphene also helps to restore the normal hormonal balance in women with PCOS, by reducing the production of androgen and increasing the production of estrogen.

In summary, Siphene works by:

  • Blocking the action of estrogen in the hypothalamus
  • Increasing the secretion of GnRH
  • Stimulating the production of FSH and LH by the pituitary gland
  • Inducing the development and release of eggs from the ovaries

Uses and Benefits of Siphene

Siphene is a medication that contains clomiphene citrate and is used to treat infertility in women. Clomiphene citrate is a selective estrogen receptor modulator (SERM) that helps to stimulate the production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in the body, which in turn can induce ovulation.

Here are some of the uses and benefits of Siphene:

  • Inducing ovulation: Siphene is commonly used to help women who are having trouble ovulating. By stimulating the production of FSH and LH, Siphene can help to trigger ovulation and increase the chances of pregnancy.

  • Treating infertility: Siphene is also used to treat infertility caused by a lack of ovulation. By helping to induce ovulation, Siphene can improve a woman’s chances of becoming pregnant.

  • Polycystic ovary syndrome (PCOS): Siphene can be used to treat PCOS, which is a hormonal disorder that can cause irregular periods, infertility, and other problems. Siphene can help to regulate the menstrual cycle and induce ovulation in women with PCOS.

  • Male infertility: Siphene can be used in men to increase the production of testosterone and improve sperm count, motility, and morphology.

  • Unexplained infertility: Siphene can be used to treat unexplained infertility, where there is no obvious cause for infertility.

  • Minimal side effects: Siphene is generally safe and has minimal side effects, making it an attractive option for women struggling with infertility.

Side Effects and Precautions of Siphene

Side Effects of Siphene

  • Hot flashes: This is the most common side effect of Siphene, and it is caused by the increase in estrogen levels in the body.

  • Abdominal discomfort: Some women may experience mild to moderate abdominal pain or discomfort while taking Siphene.

  • Headaches: Siphene can cause headaches in some women, which may range from mild to severe.

  • Mood changes: Siphene can cause mood swings, anxiety, and irritability in some women.

  • Breast tenderness or painful breasts: Some women may experience breast tenderness or enlargement while taking Siphene.

  • Nausea and vomiting: Siphene can cause nausea and vomiting in some women.

  • Visual disturbances: Rarely, Siphene can cause visual disturbances, such as blurred vision, double vision, or sensitivity to light.


  • Medical history: Women with a history of liver disease, ovarian cysts, abnormal vaginal bleeding, or blood clots should not take Siphene without consulting their doctor.

  • Pregnancy: Siphene should not be taken during pregnancy, as it can cause birth defects. Women who become pregnant while taking Siphene should stop taking it immediately and consult their doctor.

  • Multiple births: Siphene can increase the risk of multiple births (twins, triplets, etc.). Women taking Siphene should be monitored closely for signs of multiple pregnancies.

  • Driving: Siphene can cause visual disturbances, dizziness, and other side effects that may impair driving or operating machinery. Women taking Siphene should avoid driving or operating machinery until they know how it affects them.

  • Breastfeedingwarning: Siphene can pass into breast milk and may harm a nursing baby. Breastfeeding women taking Siphene should not do so while taking this medication.

  • Alcohol: Women taking Siphene should avoid alcohol, as it can increase the risk of side effects and reduce the effectiveness of the medication.

  • Dosage: Siphene should be taken as directed by a doctor. Women should not take more or less than the recommended or correct dose, or take it for longer than prescribed.

Medication Interactions With Siphene

There are several medications that can interact with Siphene, either by increasing or decreasing its effectiveness, or by causing unwanted side effects. Some of these medications include:

  • Antiestrogens: Medications such as tamoxifen or raloxifene can block the effects of Siphene and reduce its effectiveness in stimulating ovulation.

  • Gonadotropins: These medications are sometimes used in combination with Siphene to stimulate ovulation. However, they can increase the risk of ovarian hyperstimulation syndrome (OHSS), a potentially dangerous condition that can cause abdominal pain, bloating, and fluid retention.

  • Glucocorticoids: These medications can reduce the effectiveness of Siphene and may also increase the risk of side effects such as hot flashes and mood swings.

  • Thyroid hormones: Medications such as levothyroxine can affect the metabolism of Siphene and may require dosage adjustments.

  • Herbal medicines or supplements: Some herbal supplements, such as black cohosh, can interfere with the effectiveness of Siphene and should be avoided.

Dosages Of Siphene

It is important to note that the use of Siphene should only be prescribed by a licensed healthcare provider. They will determine the appropriate dose and treatment plan based on your specific needs. Typically, the recommended starting dose is 50mg daily for 5 days, usually beginning on the 5th day of the menstrual cycle. However, your healthcare provider may adjust the dose or duration of treatment based on your response to the medication.

Siphene & Sexual Health

While Siphene is not directly linked to sexual health, it can indirectly affect sexual health in some women.

Effects on libido

Some women taking Siphene may experience a decrease in libido, or sexual desire. This is because Siphene works by increasing estrogen levels, which can lead to a decrease in testosterone levels. Testosterone is the hormone responsible for sex drive in both men and women, and a decrease in testosterone can result in a decrease in libido. However, this effect is usually temporary and resolves once the medication is stopped.

Effects on vaginal dryness

Siphene can cause vaginal dryness in some women. Vaginal dryness can make sexual intercourse uncomfortable or painful, which can lead to a decrease in sexual desire. Women experiencing vaginal dryness while taking Siphene should talk to their doctor, as there are treatments available to help alleviate this symptom.

Effects on fertility

While Siphene is used to treat infertility in women, it can indirectly affect sexual health by increasing the chance of pregnancy. For women who have been struggling to conceive, the stress and anxiety of trying to get pregnant can have a negative impact on their sexual health and desire. Once pregnancy is achieved, however, many women experience an increase in sexual desire and satisfaction.

The Use Of Siphene In India

In India, Siphene is commonly prescribed by doctors for women who have difficulty getting pregnant due to ovulation problems.

Siphene works by stimulating the release of hormones necessary for ovulation, which helps increase the chances of pregnancy. It is usually prescribed for women who have irregular menstrual cycles or who do not ovulate regularly.

In India, Siphene is widely available in pharmacies and can be purchased with a prescription from a licensed medical practitioner. However, it is important to note that the use of Siphene should always be monitored by a doctor, as it can have certain side effects and risks associated with it.

It is always advisable to consult a qualified medical practitioner before starting any medication, including Siphene, as they can assess your individual medical history and provide guidance on the appropriate dosage and duration of treatment. Medical advice and monitoring when it comes to prescription drugs is critical.

Frequently Asked Questions (FAQs)

Q: How is Siphene administered?
A: Siphene is available in tablet form and is typically taken orally once a day for a specific duration, usually five days, starting on the third, fourth, or fifth day of a woman’s menstrual cycle. The exact dosage and treatment duration will depend on your doctor’s recommendations and your individual circumstances.

Q: Can men use Siphene?
A: While Siphene is primarily prescribed for women, it can also be used to treat certain types of male infertility, such as low sperm count or poor sperm motility. However, the effectiveness of Siphene in treating male infertility is less well-established, and other treatment options may be more suitable. Always consult with your doctor before starting any fertility treatment.

Q: Is it safe to take Siphene without a prescription?
A: No, it is not recommended to take Siphene without a prescription or doctor’s supervision. Fertility medications like Siphene can have significant side effects, and using them inappropriately can potentially cause harm. Always consult a healthcare professional before starting any fertility treatment.

Q: Can I take Siphene if I have a history of ovarian cysts?
A: It depends on the specific circumstances and the type of ovarian cysts. Women with a history of functional ovarian cysts may still be candidates for Siphene treatment; however, those with polycystic ovaries or other cystic conditions may need alternative treatments. It is essential to discuss your medical history with your healthcare provider to determine the best course of action.

Siphene, or clomiphene citrate, is a widely used fertility drug that has helped countless women overcome ovulatory disorders and achieve successful pregnancies. By understanding how Siphene works, its benefits, and potential side effects, individuals can make informed decisions about their fertility treatment options.

Always consult with a healthcare professional before starting any fertility treatment, and remember that each person’s journey is unique. With the right guidance and support, many couples can overcome infertility challenges and achieve their dream of parenthood.