What is Duralast?

Duralast is a brand name for the medication Dapoxetine, which is a type of medication known as a selective serotonin reuptake inhibitor (SSRI). It is primarily used to treat premature ejaculation in men. Dapoxetine works by increasing the levels of serotonin in the brain, which helps to delay ejaculation and improve control over ejaculation during sexual activity. Duralast is a prescription medication and should only be taken under the supervision of a healthcare professional.

How does Duralast Work?

The exact mechanism of action of Dapoxetine in the treatment of PE is not fully understood. Serotonin is a neurotransmitter that plays a role in regulating mood, appetite, and sleep, as well as sexual function. In the case of premature ejaculation, it is believed that the serotonin levels in the brain may be lower than normal, leading to a decrease in control over ejaculation.

Dapoxetine is a short-acting SSRI, which means that it is rapidly absorbed and eliminated from the body. This makes it an ideal medication for the treatment of PE, as it can be taken on an as-needed basis and does not need to be taken every day.

When Is Duralast Prescribed?

Duralast is primarily used to treat premature ejaculation (PE) in adult men. PE is a common sexual dysfunction in men where ejaculation occurs either before or shortly after penetration, causing distress and interpersonal difficulties.

In some cases, the medication may also be used off-label to treat other medical conditions such as depression or anxiety, as it belongs to the same class of drugs as other SSRIs used for those conditions. However, it is important to note that Duralast has not been approved by the FDA for these off-label uses and should only be used for its approved indication under the guidance of a healthcare professional.

Benefits of Duralast

  • Effective treatment: The medicationis a highly effective medication for the treatment of premature ejaculation.

  • Quick onset of action:The medication is rapidly absorbed by the body and reaches peak plasma concentrations within 1-2 hours of ingestion. This means that it starts working quickly and can help to improve sexual performance within a short period of time.

  • Safe and well-tolerated: The medication is a safe medication that is generally well-tolerated by most men. It has been extensively studied in clinical trials and has been shown to have a low incidence of side effects.

  • Easy to use: The medication comes in the form of tablets, which are easy to take with water. It is usually taken on an as-needed basis, 1-3 hours before sexual activity.

  • Improves sexual satisfaction:The medication can help to improve sexual satisfaction and quality of life for men who suffer from premature ejaculation. It can help to reduce anxiety and stress related to sexual performance and increase overall sexual confidence.

  • Compatible with other medications: The medicationis compatible with most other medications, including those used to treat erectile dysfunction. It can be used in combination with other medications to improve sexual function.

  • Available worldwide: The medication is widely available in many countries around the world, making it a convenient and accessible treatment option for men with premature ejaculation.

Usage and Dosage

The recommended dosage of Duralast medication is 30 mg/day, taken orally 1-3 hours before sexual activity.

It is important to follow the dosage instructions provided by your healthcare provider, as the optimal dose may vary depending on your individual needs and response to the medication.

The medication should be taken with a full glass of water, with or without food. It should not be taken with alcohol, as this can increase the risk of side effects.

If you miss a dose, it should be taken as soon as possible. However, if it is close to the time of your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Monitoring Duralast Use

Monitoring the effects and side effects of Duralast is important to ensure its safety and effectiveness. Here are some tests that may be used to monitor the medication:

  • Blood pressure monitoring: The medication can lower blood pressure, so your doctor may monitor your blood pressure to make sure it does not drop too low. If you have a medical history of low blood pressure or take other medications that lower blood pressure, your doctor may be particularly vigilant.

  • Liver function tests: The medicationis metabolized in the liver, so your doctor may check your liver function tests periodically to make sure that the medication is not causing any damage.

  • Serotonin syndrome: The medication can increase serotonin levels, and in rare cases, this can lead to a potentially life-threatening condition called serotonin syndrome. Symptoms of serotonin syndrome include agitation, hallucinations, rapid heartbeat, high blood pressure, muscle rigidity, and seizures. If you experience any of these symptoms, seek medical attention immediately.

  • Sexual function: The medication affects sexual function, so your doctor may ask you about your sexual health and function during follow-up visits. This will help to monitor the effectiveness of the medication and any potential side effects.

  • Mood changes: The medication can affect mood (side effects like suicidal ideation, depression and mania have been noted in some people), so your doctor may ask you about your mood during follow-up visits. If you experience any changes in mood, such as severe depression or anxiety, let your doctor know immediately.

Side effects And Precautions

Common side effects

  • Headache
  • Dizziness
  • Nausea
  • Diarrhea
  • Insomnia
  • Fatigue
  • Dry mouth

Less common side effects

  • Blurred vision
  • Ringing in the ears
  • Palpitations
  • Flushing
  • Increased blood pressure
  • Tremor
  • Anxiety
  • Lack of concentration
  • Abnormal dreams

It is important to seek medical attention if any of these side effects become severe or persistent.

In addition, there are certain precautions that should be taken:

  • The medication should not be taken by men under the age of 18 or over the age of 65.
  • It should not be taken by men with a medical history of heart disease, including heart failure or abnormal heart rhythms.
  • The medicationshould not be taken by men with a history of bleeding disorders or those taking blood-thinning medications.
  • It should not be taken by men with severe liver diseases or kidney disease or impaired kidney function
  • The medication should not be taken by women, as it is only intended for use in men.
  • It should not be taken by men who have a history of mania or severe depression, or taking certain medications, including antidepressants, antipsychotics, and certain antibiotics.

Drug Interactions With Duralast

It is important to inform your healthcare provider about all the medicines you are currently taking, including prescription and over-the-counter drugs, as well as any herbal supplements and vitamins, before starting treatment with Duralast.

Here are some medicines that may interact with Duralast:

  • Monoamine oxidase inhibitors (MAOIs): These are a class of antidepressant medications that should not be taken with Duralast due to the risk of serotonin syndrome, a potentially life-threatening condition.

  • Serotonin-norepinephrine reuptake inhibitors (SNRIs): The medicationmay interact with SNRIs such as venlafaxine and duloxetine, increasing the risk of serotonin syndrome.

  • Selective serotonin reuptake inhibitors (SSRIs): These medications are commonly used to treat depression and anxiety, and may interact with Duralast, potentially increasing the risk of serotonin syndrome.

  • Tricyclic antidepressants: These medications may interact with Duralast and increase the risk of serotonin syndrome.

  • Medications that prolong the QT interval: Duralast may prolong the QT interval, which is the time it takes for the heart to recharge after each heartbeat. Taking Duralast with other medications that also prolong the QT interval, such as certain antibiotics, antifungal medications, and antipsychotic medications, may increase the risk of abnormal heart rhythms.

  • Blood thinners: The medication may increase the risk of bleeding when taken with blood thinners such as warfarin, heparin, and aspirin.

  • Alcohol: Drinking alcohol while taking the medication may increase the risk of side effects such as dizziness, lightheadedness, and fainting.

Duralast: Positive & Negative Effects On Sexual Health

While Duralast can be effective in treating premature ejaculation, it can also have both positive and negative effects on sexual health.

Positive effects of Duralast on sexual health

  • Improved control over ejaculation: Duralast is designed to help men last longer during sexual activity. By delaying ejaculation, men may be able to have more satisfying sexual experiences.

  • Increased confidence: Men who suffer from premature ejaculation may experience a decrease in confidence and self-esteem. By treating the condition with Duralast, men may feel more confident in their sexual abilities.

Negative effects of Duralast on sexual health

  • Reduced libido: While Duralast can improve control over ejaculation, it may also reduce libido and sexual desire. This is because dapoxetine, the active ingredient in Duralast, can affect serotonin levels in the brain, which can impact sexual desire.

  • Erectile dysfunction: Some men may experience difficulty achieving or maintaining an erection while taking Duralast. This side effect is not common, but it can occur in some cases.

  • Delayed orgasm: While Duralast can help delay ejaculation, it may also delay orgasm or make it more difficult to achieve. This can be frustrating for some men and their partners.


Q: Can I take Duralast with alcohol? A: It is generally recommended to avoid consuming alcohol while taking Duralast, as it may increase the risk of side effects such as dizziness, drowsiness, and fainting.

Q: How long does the effect of Duralast last? A: The effects of Duralast typically last for several hours, depending on individual factors such as metabolism, weight, and overall health.

Q: Can I take Duralast with other medications for erectile dysfunction (ED)? A: Duralast can be taken alongside ED medications such as Viagra, Cialis, and Levitra. However, it is important to consult with your healthcare provider before combining medications to ensure safety and avoid potential drug interactions.

Q: Is Duralast available without a prescription? A: Duralast is a prescription medication and should only be taken under the guidance of a healthcare professional. Do not attempt to purchase or use Duralast without a valid prescription.

Q: Can women take Duralast? A: Duralast is specifically designed to treat premature ejaculation in men and is not intended for use by women. If you are a woman experiencing sexual dysfunction, consult your healthcare provider for appropriate treatment options.

Duralast, a medication containing dapoxetine, offers a promising solution for men struggling with premature ejaculation. By improving control over ejaculation, Duralast can enhance sexual satisfaction and reduce the stress and anxiety associated with PE. As with any medication, it is essential to consult a healthcare professional before starting Duralast and to follow the prescribed dosage guidelines.