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Avanafil vs. Tadalafil: Comparing Two Popular Erectile Dysfunction Treatments

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09 May, 2023
Exploring the Differences and Benefits of Avanafil and Tadalafil
Avanafil vs Tadalafil


Erectile dysfunction (ED) affects millions of men worldwide, causing emotional distress and relationship issues. Fortunately, modern medicine has brought forth a variety of treatment options, with avanafil and tadalafil being two of the most popular choices in the treatment of Erectile Dysfunction. This comprehensive article explores their similarities, differences, and potential side effects to help you make an informed decision about which medication is best for you.

Overview of Avanafil and Tadalafil


Avanafil (brand name: Stendra) and tadalafil (brand name: Cialis) are both FDA-approved medications for the treatment of erectile dysfunction. They belong to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors, which also include sildenafil (Viagra) and vardenafil (Levitra).


Despite being in the same drug class, avanafil and tadalafil have different chemical structures, which results in varying onset times, durations of action, and potential side effects. This section will provide a brief introduction to each medication which will help you determine the more convenient option out of the two to achieve relief from erectile dysfunction.




Avanafil was approved by the FDA in 2012 for relief from erectile dysfunction, making it the newest addition to the PDE5 inhibitor family. It’s known for its fast-acting properties and relatively fewer side effects.


It is available in India under the brand name Stendra. The medication is marketed by several pharmaceutical companies in India for relief from erectile dysfunction, including Abbott Healthcare Pvt. Ltd., Ind-Swift Laboratories Ltd., and Macleods Pharmaceuticals Ltd.




Tadalafil was approved by the FDA in 2003 and has since gained popularity for its long-lasting effects. It’s available in two dosing options: as-needed and daily use, providing flexibility for those who require frequent treatment of erectile dysfunction.


Tadalafil is a medication used in the treatment of erectile dysfunction and is available in India under the brand name Cialis for relief from erectile dysfunction. According to a report by IQVIA, a leading global provider of healthcare data and analytics, in 2020, tadalafil was among the top 100 drugs by sales in India, with a total value of over Rs. 900 crores. Tadalafil is marketed in India by several pharmaceutical companies, including Eli Lilly and Company (India) Pvt. Ltd., Sun Pharmaceutical Industries Ltd., and Ajanta Pharma Ltd.

How Avanafil and Tadalafil Work


Avanafil and tadalafil work by inhibiting the PDE5 enzyme, which is responsible for breaking down cyclic guanosine monophosphate (cGMP). As a result, cGMP levels increase, leading to the relaxation of smooth muscles in the blood vessels of the penis. This relaxation allows blood to flow more easily into the erectile tissue, leading to an erection in response to sexual stimulation.

Comparing Effectiveness


When comparing the effectiveness of avanafil and tadalafil, several factors come into play, including onset time, duration of action, and overall efficacy.


Onset of action


Avanafil is known for its fast-acting properties, with most patients with Erectile Dysfunction experiencing the desired effects within 15 to 30 minutes of taking the medication thus having a faster onset. On the other hand, tadalafil typically takes 30 to 45 minutes to become effective.


Duration of Action


Tadalafil has earned the nickname “the weekend pill” due to its long-lasting effects in patients with erectile dysfunction. Its duration of action can be up to 36 hours, while avanafil’s effects usually last for 4 to 6 hours.


Overall Efficacy


Both avanafil and tadalafil have been shown to be effective in the treatment of erectile dysfunction. However, individual responses to each medication may vary, and factors such as age, overall health, and how severe erectile dysfunction is, can impact treatment outcomes.


Cost Comparison


As of April 2023, the approximate cost of avanafil (Stendra) for a 50 mg tablet ranges from Rs. 150 to Rs. 250, while a 200 mg tablet costs between Rs. 400 to Rs. 600, depending on the brand and pharmacy.


The approximate cost of tadalafil (Cialis) for a 10 mg tablet ranges from Rs. 70 to Rs. 100, while a 20 mg tablet costs between Rs. 120 to Rs. 200, depending on the brand and pharmacy.


It is important to note that the affordable option is not always the convenient option in erectile dysfunction treatment. Patients with Erectile Dysfunction need to consider all factors of drug comparisons before selecting the right one for them.

Side Effects and Safety

Male doctor shows by hands the number of side effects when taking the drug. Medical exam in doctor's hospital office.

Like all medications, avanafil and tadalafil can cause side effects. It’s essential to be aware of these potential risks before starting treatment. The following are the most common side effects associated with each medication:



  • Headache

  • Flushing

  • Nasal congestion

  • Back pain

  • Dizziness




  • Headache

  • Indigestion

  • Back pain

  • Muscle aches

  • Flushing

  • Nasal congestion

While the side effects of both medications are generally mild and well-tolerated, it’s important to seek medical attention if you experience persistent or severe side effects. Seek medical attention immediately if they persist.

Drug Interactions

Two pink arrows made by pills among many different medical table

Certain medications can interact with avanafil and tadalafil, potentially leading to adverse effects or reduced effectiveness. It’s crucial to inform your healthcare provider of all medications you’re currently taking, including prescription, over-the-counter, and herbal products. Some common drug interactions to be aware of include:

  • Nitrates (e.g., nitroglycerin): This can cause a dangerous drop in blood pressure when taken with avanafil or tadalafil.

  • Alpha-blockers (e.g., tamsulosin): This can lead to low blood pressure when combined with either avanafil or tadalafil.

  • Antifungal medications (e.g., ketoconazole): May increase the levels of avanafil or tadalafil in the bloodstream, potentially causing side effects.

Which Medication is Right for You?


Choosing between avanafil and tadalafil ultimately depends on your individual needs and preferences. Some factors to consider include:

  • Onset time: If a fast-acting medication is important to you, avanafil may be the better choice as it has a quicker onset.

  • Duration of action: If you prefer a longer-lasting effect, tadalafil might be more suitable.

  • Side effects: You may respond differently to each medication, so it’s essential to consider your own experiences with side effects.

  • Cost: Prices for avanafil and tadalafil can vary, so take into account the cost of each medication and whether it’s covered by your insurance.

It’s crucial to consult with a healthcare professional to discuss your specific situation and determine the best course of action.

Frequently Asked Questions


Q: Can I take avanafil or tadalafil with alcohol?

A: While moderate alcohol consumption is generally safe, excessive alcohol intake can increase the risk of side effects and decrease the effectiveness of these medications.


Q: How should I take avanafil or tadalafil?

A: Always follow your healthcare provider’s instructions for taking these medications. Typically, avanafil is taken as needed, 15 to 30 minutes before sexual activity. Tadalafil can be taken as needed, 30 to 45 minutes before sexual activity, or once daily at a lower dose.


Q: Can I take both avanafil and tadalafil together?

A: No, you should never combine avanafil and tadalafil, as this can increase the risk of side effects and adverse reactions.



Avanafil and tadalafil are both effective treatments for patients with erectile dysfunction, each with its own unique benefits and potential side effects. When deciding between these two medications, it’s essential to consider your individual needs and consult with a healthcare professional to determine the best course of treatment. By understanding the differences between avanafil and tadalafil, you can make a well-informed decision and take a significant step toward improving your sexual health and quality of life.

Sexual health is as important as physical and mental health. In most cases, one consultation can go a long way. Personalised, discreet, and judgement-free treatment at your fingertips – book an online consultation with one of Allo’s leading experts.